Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.
نویسندگان
چکیده
A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity. The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium falciparum can be imparted by the introduction of a methoxy group ortho to the acetylenic group. Most compounds were more active against non-replicating than replicating cultures of Mycobacterium tuberculosis H(37)Rv, an unusual pattern with respect to existing anti-TB agents.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 20 3 شماره
صفحات -
تاریخ انتشار 2010